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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: IGF1R All Species: 22.73
Human Site: Y70 Identified Species: 50
UniProt: P08069 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0.1
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P08069 NP_000866.1 1367 154793 Y70 L I S K A E D Y R S Y R F P K
Chimpanzee Pan troglodytes XP_510613 1364 154513 Y70 L I S K A E D Y R S Y R F P K
Rhesus Macaque Macaca mulatta XP_001100407 1367 154946 Y70 L I S K A E D Y R S Y R F P K
Dog Lupus familis XP_545828 1367 154872 Y70 L I S K A E D Y R S Y R F P K
Cat Felis silvestris
Mouse Mus musculus Q60751 1373 155770 Y70 L I S K A E D Y R S Y R F P K
Rat Rattus norvegicus P24062 1370 155377 Y70 L I S K A E D Y R S Y R F P K
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus P08941 2311 260942 Q326 L E A A H C L Q N G I I H H N
Frog Xenopus laevis O73798 1358 153845 L70 K A E D F R N L R F P N L T V
Zebra Danio Brachydanio rerio NP_694500 1405 158428 F76 N N L N Q E H F R T L S F P K
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P09208 2144 239757 P374 D L I N D A S P L N R S F P K
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q968Y9 1846 207106 D215 L Q P R Y S Q D E F I T F P H
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.7 99.5 98.2 N.A. 95.6 95.7 N.A. N.A. 21.3 75.5 66.6 N.A. 26.8 N.A. 27 N.A.
Protein Similarity: 100 99.7 99.6 98.8 N.A. 97.8 98 N.A. N.A. 35.5 85.9 79.2 N.A. 40.3 N.A. 41.5 N.A.
P-Site Identity: 100 100 100 100 N.A. 100 100 N.A. N.A. 6.6 6.6 33.3 N.A. 20 N.A. 20 N.A.
P-Site Similarity: 100 100 100 100 N.A. 100 100 N.A. N.A. 13.3 13.3 46.6 N.A. 33.3 N.A. 26.6 N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 10 10 10 55 10 0 0 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 10 0 0 0 0 0 0 0 0 0 % C
% Asp: 10 0 0 10 10 0 55 10 0 0 0 0 0 0 0 % D
% Glu: 0 10 10 0 0 64 0 0 10 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 10 0 0 10 0 19 0 0 82 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 0 10 0 0 0 0 0 % G
% His: 0 0 0 0 10 0 10 0 0 0 0 0 10 10 10 % H
% Ile: 0 55 10 0 0 0 0 0 0 0 19 10 0 0 0 % I
% Lys: 10 0 0 55 0 0 0 0 0 0 0 0 0 0 73 % K
% Leu: 73 10 10 0 0 0 10 10 10 0 10 0 10 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 10 10 0 19 0 0 10 0 10 10 0 10 0 0 10 % N
% Pro: 0 0 10 0 0 0 0 10 0 0 10 0 0 82 0 % P
% Gln: 0 10 0 0 10 0 10 10 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 10 0 10 0 0 73 0 10 55 0 0 0 % R
% Ser: 0 0 55 0 0 10 10 0 0 55 0 19 0 0 0 % S
% Thr: 0 0 0 0 0 0 0 0 0 10 0 10 0 10 0 % T
% Val: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 10 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 10 0 0 55 0 0 55 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _